Slay the Spire 2 Wiki, Cards, Builds & Strategy Guides

Strength increases the damage of each Attack card by 1 per stack. The Ironclad specializes in building Strength through cards like Inflame, Limit Break, and Spot Weakness. Strength is the most direct scaling mechanic in Slay the Spire 2 and works particularly well with multi-hit STS2 attacks, where each hit benefits from the full bonus.

Poison is a debuff that deals damage equal to its stack count at the start of the affected enemy's turn, then decreases by half (rounded down). The Silent is the master of Poison in STS2. Poison bypasses block entirely, making it one of the most effective ways to deal with high-armor enemies in Slay the Spire 2. Stack multiple poison cards for exponential damage scaling.

Orbs are passive abilities that automatically activate each turn. The Defect channels three orb types in STS2: Lightning orbs deal damage to a random enemy, Frost orbs generate block, and Plasma orbs provide bonus energy. Focus increases the effectiveness of all orbs in Slay the Spire 2, while orb slots determine how many you can have active. Evoking an orb triggers its passive effect and replaces it with a new one.

Exhaust removes a card from your STS2 deck for the rest of combat. The Ironclad uses exhaust strategically to thin their deck, remove weak cards, and activate powerful synergies. Cards with exhaust often have above-average effects to compensate for their single-use nature in Slay the Spire 2. Exhaust-based builds are among the strongest strategies in the game.

The Necrobinder summons minion armies that fight alongside them in STS2, overwhelming enemies through numbers and coordinated attacks. The Regent builds resource engines using Stars, generating energy and scaling effects that spiral out of control. These two new STS2 characters from Slay the Spire 2 introduce completely unique mechanics not seen in the original game.